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Roizman, Bernard
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Item TypeName
Concept Gene Deletion
Academic Article Activation of NF-kappaB in cells productively infected with HSV-1 depends on activated protein kinase R and plays no apparent role in blocking apoptosis.
Academic Article Herpes simplex virus 1 mutant in which the ICP0 HUL-1 E3 ubiquitin ligase site is disrupted stabilizes cdc34 but degrades D-type cyclins and exhibits diminished neurotoxicity.
Academic Article Glycoprotein M of herpes simplex virus 1 is incorporated into virions during budding at the inner nuclear membrane.
Academic Article Expression of gamma interferon-dependent genes is blocked independently by virion host shutoff RNase and by US3 protein kinase.
Academic Article Replication-competent herpes simplex virus 1 isolates selected from cells transfected with a bacterial artificial chromosome DNA lacking only the UL49 gene vary with respect to the defect in the UL41 gene encoding host shutoff RNase.
Academic Article Systemic delivery of (gamma1)34.5-deleted herpes simplex virus-1 selectively targets and treats distant human xenograft tumors that express high MEK activity.
Academic Article Characterization of a recombinant herpes simplex virus 1 designed to enter cells via the IL13Ralpha2 receptor of malignant glioma cells.
Academic Article Glycoprotein D or J delivered in trans blocks apoptosis in SK-N-SH cells induced by a herpes simplex virus 1 mutant lacking intact genes expressing both glycoproteins.
Academic Article Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the UL47 tegument protein.
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  • Gene Deletion